Third-generation GMP lentivirus packaging plasmids, manufactured in compliance with the highest regulatory standards, featuring active DMF to streamline the LVV IND review process.
The ready-to-use fully released GMP grade pGagPol, pRev, pVSV-G, will accelerate your GMP LVV production.
uBriGene has assisted our clients in obtaining CAR-T IND clearance using LVV manufactured with these lentivirus packaging plasmids.
Manufactured and released in compliance with the highest regulatory standards.
R&D and GMP grade LVV packaging plasmids available
Loyalty-free from uBriGene
DMF files with the FDA
The various Rep/Cap plasmids and helper plasmids have been tested for high quality and high yield in GMP AAV production.
We have assisted our clients in obtaining IND clearance with AAV produced using these AAV helper plasmids.
| Product Name | Catalog Number | Description | R&D Grade | GMP Grade | E. Coli Selection | Price |
|---|---|---|---|---|---|---|
| Hex-VSVG | 1302HEX-VSVG | pVSV-G envelope plasmid for pseudo lentivirus packaging | Yes | Yes | KanR | |
| Hex-MDL | 1302HEX-MDL | pGag-Pol plasmid for lentivirus packaging | Yes | Yes | KanR | Please Inquire |
| Hex-Rev | 1302HEX-REV | pRev plasmid for lentivirus packaging | Yes | Yes | KanR |
Ready for LVV GMP production
GMP pGagPol, pRev, pVSV-G plasmids
Active DMF with the FDA
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Automated closed-system technology for manufacturing ensures sterility with functionally closed disposables, minimizes operator errors through pre-programmed steps, and enhances consistency by reducing variability. It also reduces technician hands-on time and lowers production costs.
Extensive plasmid production experience
100+ GMP plasmid projects annually
Our third-generation lentivirus packaging plasmids are used in our LVV manufacturing. High quality and high yield of lentiviruses are produced with our proprietary LVV suspension production cell line, 293TH. Transduction titer is measured after transducing Jurkat cells, ranging from 1-5 E7 TU/mL, depending on the target genes.
uBriGene’s lentivirus packaging plasmids were used for lentiviral vector production with uBriGene’s proprietary LVV suspension cell bank, 293TH. Transduction titer was measured using flow cytometry after transducing Jurkat cells.
As a world leading plasmid DNA manufacturing CDMO provider, we provide exceptional QA and QC support, with most plasmid QC release assays performed in-house.
Our off-the-shelf lentivirus packaging plasmids are manufactured and released in strict compliance with the highest regulatory standards. A certificate of analysis will be provided with each of the GMP grade lentiviral packaging plasmids.
| Test Items | Method | |
|---|---|---|
| Appearance | Visual inspection | |
| pH | pH measurement | |
| Concentration | UV, Spectrophotometry | |
| Identity | Restriction analysis | Gel electrophoresis |
| Target sequence analysis* | Sanger sequencing | |
| Purity | A260/A280 | UV, Spectrophotometry |
| Supercoiled plasmid ratio | HPLC | |
| Residuals | Residual E. Coli DNA | qPCR |
| Residual E. Coli RNA | Gel electrophoresis/HPLC | |
| Residual E. Coli protein | ELISA | |
| Safety | Endotoxin | Gel-clot assay |
| Sterility | Membrane filtration method | |
Explore uBriGene’s robust GMP plasmid manufacturing process and testing capabilities.
Unveil the current manufacturing approaches for LVV and its deployment in cell therapies
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GMP lentiviral packaging plasmids will provide lentiviral vector packaging proteins and envelope proteins for lentiviral vector packaging inside production cells under Good Manufacturing Practices (GMP). These GMP lentivirus plasmids meet stringent regulatory standards, ensuring the quality, safety, and consistency required for clinical applications, such as CAR-T therapies and gene therapy products.
We provide GMP-grade third-generation lentiviral packaging plasmids, including pGagPol, pRev, and pVSV-G. These GMP plasmids are ready-to-use and fully released to accelerate your lentiviral vector (LVV) production.
Our GMP lentiviral packaging plasmids come with active Drug Master Files (DMF) on file with the FDA. This helps streamline regulatory submissions and reduces the time needed for the IND review process, making it easier to advance your cell and gene therapy products to clinical trials.
Yes, our GMP-grade lentiviral packaging plasmids are specifically designed for clinical-grade LVV production, adhering to the highest regulatory standards for use in preclinical, clinical, and commercial applications.
Our lentiviral packaging plasmids are manufactured in compliance with GMP standards and are designed to deliver high-quality, high-yield lentiviral vectors. Using our proprietary LVV suspension cell line, 293TH, we have helped clients achieve robust lentivirus production and successful IND clearance.
Our GMP lentiviral packaging plasmids are fully scalable for lentiviral vector production, supporting both small-scale research needs and large-scale clinical manufacturing.
Our lentivirus GMP plasmids undergo rigorous in-house quality control testing, including identity, purity, and safety assays, to ensure compliance with GMP regulatory standards and reliable performance in lentiviral vector production.
Yes, our GMP lentiviral packaging plasmids are available royalty-free, offering cost-effective solutions for your LVV manufacturing needs.
Our off-the-shelf GMP lentiviral packaging plasmids are readily available, and we typically ship them within 1–2 weeks after order confirmation.
Extensive expertise with a track record of successfully releasing over 60 GMP batches of AAV.
GMP grade pGagPol, pRev, pVSV-G
Active DMF with the FDA
Proven - LVV produced using the Lentivirus packaging plasmids received IND clearance
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Ask the plasmid DNA expert! With over 300 GMP batches in our track record and our cost-effective platform technology, we can help accelerate your clinical programs.
